Control of sympathetic vasomotor tone by catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata

N Marina; APL Abdala; A Korsak; AE Simms; AM Allen; JFR Paton; AV Gourine

Journal article

Control of sympathetic vasomotor tone by catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata

N Marina, APL Abdala, A Korsak, AE Simms, AM Allen, JFR Paton, AV Gourine

Cardiovascular Research | OXFORD UNIV PRESS | Published : 2011

DOI: 10.1093/cvr/cvr128

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Abstract

Aims Increased sympathetic tone in obstructive sleep apnoea results from recurrent episodes of systemic hypoxia and hypercapnia and might be an important contributor to the development of cardiovascular disease. In this study, we re-evaluated the role of a specific population of sympathoexcitatory catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata in the control of sympathetic vasomotor tone, arterial blood pressure, and hypercapnia-evoked sympathetic and cardiovascular responses. Methods and resultsIn anaesthetized rats in vivo and perfused rat working heart brainstem preparations in situ, C1 neurones were acutely silenced by application of the insect peptide allat..

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University of Melbourne Researchers

Andrew Allen Author

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Awarded by Wellcome Trust

Funding Acknowledgements

This work was supported by the British Heart Foundation (grant numbers PG/08/009/24411 and RJ/07/006); The Wellcome Trust (grant number 079040); The Australian Research Council (grant number DP1094301); and The National Health and Medical Research Council of Australia (grant number 628838). J.F.R.P. is the recipient of a Royal Society Wolfson Research Merit Award; A. V. G. is a Wellcome Trust Senior Research Fellow. Funding to pay Open Access charges was provided by The Wellcome Trust.